Zentalis : Discovering and developing best-in-class small molecule therapeutics targeting fundamental biological cancer pathways. Pipeline includes ZN-c3, a WEE1 inhibitor for advanced solid tumors (currently enrolling a Ph 2 Fast Track trial in USC and planning to initiate a potentially registrational biomarker-driven trial), ZN-c5, an oral SERD for breast cancer, ZN-d5, a BCL-2 inhibitor for hematologic malignancies, and ZN-e4, an EGFR inhibitor for NSCLC. Multiple mono and combo trials are ongoing/planned across pipeline.
Based in...
US - Middle Atlantic
Clinical Stage
Phase l or ll
Disease Space
Public, USA
Market Cap
1B +
530 Seventh Avenue, Ste 2201
Corner of 39 St
New York, NY 10018
United States

Company Participants at Zentalis R&D Day

  • Anthony Sun, CEO

Lead Programs

ZN-c5: Oral SERD

oral selective estrogen receptor degrader (SERD)

Indication Phase
Breast Cancer 1/2

ZN-c3: WEE1

oral inhibitor of WEE1

Indication Phase
Solid Tumors 1/2

ZN-d5: BCL-2

oral selective inhibitor of B-cell lymphoma 2 (BCL-2)

Indication Phase
Hematologic Malignancies IND


oral, small molecule inhibitor of mutant epidermal growth factor receptor (EGFR)

Indication Phase

Top 10 Holders of Zentalis Pharmaceuticals, Inc.

Institution OS (%) Position Mkt Val ($MM) Source Filing Date
Fidelity Management & Research Co. LLC 12.85 5,855,415 131.22 13F 3/31/22
Matrix Capital Management Co. LP 9.55 4,349,279 97.47 13F 3/31/22
T. Rowe Price Associates, Inc. (Investment Management) 9.21 4,198,180 94.08 13F 3/31/22
The Vanguard Group, Inc. 7.03 3,186,986 71.42 Stakes 12/31/21
Avidity Partners Management LP 6.97 3,176,999 71.20 13F 3/31/22
Vanguard Group, Inc. (Subfiler) 6.91 3,148,449 70.56 13F 3/31/22
Tybourne Capital Management (HK) Ltd. 5.32 2,426,095 54.37 13F 3/31/22
State Street Corp. 4.57 2,080,440 46.62 13F 3/31/22
Viking Global Investors LP 4.45 2,026,656 45.42 13F 3/31/22
BlackRock Fund Advisors 3.33 1,516,533 33.99 13F 3/31/22
Ownership data is sourced through FactSet.

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